Question: What Diseases Cause Low IgG?

How common is IgG deficiency?

IgG2 or IgG3 deficiencies are the most common IgG subclass deficiencies.

Since IgG1 comprises 60% of the total IgG level, deficiency of IgG1 usually drops the total IgG level below the normal range, resulting in hypogammaglobulinemia.

IgG subclass deficiencies may be associated with other immunoglobulin abnormalities..

How can I increase my IgG level?

Eat Right Garlic. Omega-3 fatty acids, found in nuts, salmon, tuna, mackerel, and flaxseed oil. Zinc-rich foods, like oysters, crab, lean meats and poultry, and chickpeas. Selenium-rich foods, such as broccoli, sardines, tuna, brazil nuts, and barley.

What causes low IgM levels?

Other causes of decreased levels of serum IgM (i.e., secondary IgM deficiency) are episodes of infection, thymic hypoplasia, celiac disease, autoimmune disease, and certain adult malignancies; and other PIDs (Wiskott-Aldrich syndrome, DOCK8 deficiency, ataxia-telangiectasia, CVID, and XLA, in combination with IgG and …

What causes antibodies to be low?

Low levels of immunoglobulins mean your immune system isn’t working as well as it should. This can be caused by: Medicines that weaken your immune system, such as steroids. Diabetes complications.

Can IgG deficiency be cured?

Currently, the accepted therapy for IgG deficiency is the intravenous administration of 300-600 mg/kg of IgG once every 3-4 weeks, or 100-200 mg/kg/wk subcutaneously. Higher doses have been shown to be more effective in reducing infections in patients with histories of chronic or recurrent sinopulmonary infections.

Is low IgG serious?

People with IgG deficiency are more likely to get infections. Although researchers don’t know what causes primary IgG deficiency, genetics may play a role. When the symptoms come on later in life, the health problem is harder to manage, and you may have more infections.

What do low IgG levels mean?

An IgG deficiency is a health problem in which your body doesn’t make enough Immunoglobulin G (IgG). People with IgG deficiency are more likely to get infections. … These antibodies are made by B cells and plasma cells. They are let loose throughout the body to help kill bacteria, viruses, and other germs.

Is IgG deficiency an autoimmune disease?

Autoimmune diseases were more frequent in CVID patients (37.1 %) than in those with selective IgA deficiency (25.5 %) or selective IgG subclass deficiency (12.5 %). Thirty-seven percent of autoimmune episodes occurred prior to the diagnosis of primary antibody deficiency.

What are IgG levels in blood?

This test measures the amount of immunoglobulins, also known as antibodies, in your blood. … An immunoglobulins test usually measures three specific types of immunoglobulins. They are called igG, igM, and IgA. If your levels of igG, igM, or IgA are too low or too high, it may be a sign of a serious health problem.

What is normal IgG level in adults?

Specific laboratory determinations The manufacturer indicates the following reference intervals for healthy adults: IgA 70–400 mg/dl, IgG 700–1600 mg/dl and IgM 40–230 mg/dl [35].

Why is IgG better than IgM?

IgM is specialized to activate complement efficiently upon binding antigen. IgG antibodies are usually of higher affinity and are found in blood and in extracellular fluid, where they can neutralize toxins, viruses, and bacteria, opsonize them for phagocytosis, and activate the complement system.

What causes low IgG and IgM levels?

Low levels of IgG occur in macroglobulinemia. In this disease, the high levels of IgM antibodies stop the growth of cells that make IgG. Other conditions that can cause low levels of IgG include some types of leukemia and a type of kidney damage (nephrotic syndrome).

What does a low IgG subclass 1 mean?

IgG subclass deficiency is defined as the decrease of one or more subclasses of IgG antibodies with normal or near normal levels of other immunoglobulin classes. … Children with IgG subclass deficiency present most commonly with recurrent ear infections, sometimes as early as the second year of life.

Can low IgG levels cause fatigue?

Isolated IgG1 deficiency has been reported in chronic fatigue syndrome. As IgG1 is the most abundant IgG subclass, its deficiency often results in hypogammaglobulinemia. Conversely, IgG2 and IgG4 deficiencies manifest in the form of otitis media and sinusitis.

What are the symptoms of low IgG?

What are the symptoms of an IgG deficiency?Sinus infections and other respiratory infections.Digestive tract infections.Ear infections.Pneumonia.Bronchitis that keeps coming back. It can lead to permanent lung damage.Infections that cause a sore throat.Severe and life-threatening infections (rare)

How can I increase my IgG naturally?

Eat RightGarlic.Omega-3 fatty acids, found in nuts, salmon, tuna, mackerel, and flaxseed oil.Zinc-rich foods, like oysters, crab, lean meats and poultry, and chickpeas.Selenium-rich foods, such as broccoli, sardines, tuna, brazil nuts, and barley.More items…•

What is the normal range of IgG?

immunoglobulin g normal range The IgG normal range for age 0-1 years is between 231-1411 mg/dL. The IgG normal range for age 1-3 years is between 453-916 mg/dL. The Immunoglobulin normal range for age 4-6 years is between 504-1464 mg/dL. The Immunoglobulin normal range for age 7-9 years is between 572-1474 mg/dL.